Nuclear Factor I Represses the Notch Effector HEY1 in Glioblastoma
نویسندگان
چکیده
منابع مشابه
A role for the transcription factor HEY1 in glioblastoma
Abstract Glioblastoma multiforme (GBM), the highest-grade glioma, is the most frequent tumour of the brain with a very poor prognosis and limited therapeutic options. Although little is known about the molecular mechanisms that underlie glioblastoma formation, a number of signal transduction routes, such as the Notch and Ras signalling pathways, seem to play an important role in the formation o...
متن کاملLatency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus promotes angiogenesis through targeting notch signaling effector Hey1.
Notch signaling has been implicated in the pathogenesis of Kaposi sarcoma. Kaposi sarcoma is an angioproliferative neoplasm that originates from Kaposi sarcoma-associated herpesvirus (KSHV) infection. Previously, we showed that the KSHV LANA protein can stabilize intracellular Notch in KSHV-infected tumor cells and promote cell proliferation. However, whether Notch signaling functions in pathol...
متن کاملMethylation regulates HEY1 expression in glioblastoma
Glioblastoma (GBM) remains one of the most lethal and difficult-to-treat cancers of the central nervous system. The poor prognosis in GBM patients is due in part to its resistance to available treatments, which calls for identifying novel molecular therapeutic targets. In this study, we identified a mediator of Notch signaling, HEY1, whose methylation status contributes to the pathogenesis of G...
متن کاملInhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis.
PURPOSE Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and remains refractory to combined-modality therapy in patients with high risk disease. In skeletal myogenesis, Notch signaling prevents muscle differentiation and promotes proliferation of satellite cell progeny. Given its physiologic role in myogenesis and oncogenic role in other human cancers, we hypothesized ...
متن کاملMolecular and Cellular Pathobiology Latency-Associated Nuclear Antigen of Kaposi Sarcoma– Associated Herpesvirus Promotes Angiogenesis through Targeting Notch Signaling Effector Hey1
Notch signaling has been implicated in the pathogenesis of Kaposi sarcoma. Kaposi sarcoma is an angioproliferative neoplasm that originates fromKaposi sarcoma–associated herpesvirus (KSHV) infection. Previously, we showed that the KSHV LANA protein can stabilize intracellular Notch in KSHV-infected tumor cells and promote cell proliferation. However, whether Notch signaling functions in patholo...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2018
ISSN: 1476-5586
DOI: 10.1016/j.neo.2018.08.007